Characteristics of multiple sclerosis patient stance control disorders, measured by means of posturography and related to brainstem lesions

  • Dario Alpini Scientific Institute S. Maria Nascente, Don Carlo Gnocchi Foundation, Milan, Italy.
  • Federica Di Berardino | federica.diberardino@unimi.it Dipartimento di Scienze Chirurgiche Specialistiche, Università degli Studi di Milano, Milan, Italy.
  • Valentina Mattei Scientific Institute S. Maria Nascente, Don Carlo Gnocchi Foundation, Milan, Italy.
  • Domenico Caputo Scientific Institute S. Maria Nascente, Don Carlo Gnocchi Foundation, Milan, Italy.
  • Peter Schalek ENT Institute III Medical Faculty Charles University, Prague, Czechia.
  • Antonio Cesarani Dipartimento di Scienze Chirurgiche Specialistiche, Università degli Studi di Milano, Milan; Audiology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy.

Abstract

Balance disorders are commonly observed during the course of multiple sclerosis (MS). The aim of this study is to report characteristics of MS patient stance control disorders, measured by means of posturography and related to the brainstem lesions. Thirty-eight patients affected by MS, mildly to moderately disable according to Kurtzke’s Expanded Disability Status Scale, underwent a complete clinical neurological and vestibular evaluation and brain MRI scanning. All patients were then tested on a static posturography platform (Tetrax, Israel) in four conditions: eyes open and eyes closed standing on a firm surface and on a foam pad. Clinical and/or magnetic resonance imaging evidence of brainstem involvement was observed in 55.3% of patients. When brainstem lesion was detected, Fourier analysis showed a typical pattern characterized by inversion of the 0- 0.1 Hz and 0.1-0.25 Hz frequency bands. In conclusion, MS leads to pervasive postural disturbances in the majority of subjects, including the visuo-vestibular loops and proprioception involving vestibulospinal pathways in at least 55.3% of patients. Our results may also suggest the presence of Fourier inversion in patients with brainstem lesions.

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Published
2012-01-13
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Original Articles
Keywords:
multiple sclerosis, magnetic resonance imaging, posturography, vestibulo-spinal reflex.
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How to Cite
Alpini, D., Di Berardino, F., Mattei, V., Caputo, D., Schalek, P., & Cesarani, A. (2012). Characteristics of multiple sclerosis patient stance control disorders, measured by means of posturography and related to brainstem lesions. Audiology Research, 2(1), e9. https://doi.org/10.4081/audiores.2012.e9